Yes, you can roll the top up, put the straps on it and remove it leaving the rails in place. Another thing I really like about this cover is when you roll it back to latch it latches really easy. especially compared to others I've used in the past.
Another good option for tonneau covers is https://truxedo.com/sentry/2022/ford/f-150
I have this one on my 22 Tremor. One of the nice features is the quick release feature being able to remove the cover if you need the space in your bed.